Antifungal activity of SN 105-843 gel in vivo.

The present work deals with the antifungal activity of SN 105-843 (Naftifine) against dermatophytes in vivo. Fifty cases suffering from various types of dermatomycoses were studied from November 1979 to September l980. The patients were supplied with 1% gel preparation of SN 105-843 for local application on the lesion for a period of 2-8 weeks. The results indicate that the drug has very significant antifungal effect on all types of dermatomycoses Out of fifty cases studied, thirty-two (64%) were cured, fifteen (30%) improved and in the remaining 3 cases (6%) the therapy had to be discontinued due to significant side-effect in the form of burning. SN 105-843 seems to be an effective antifungal agent (JPMA 31:123, 1981).